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Title: New intracellular components of bone morphogenetic protein/Smad signaling cascades
Authors: Zwijsen, An ×
Verschueren, Kristin
Huylebroeck, Danny #
Issue Date: Jun-2003
Series Title: FEBS Letters vol:546 issue:1 pages:133-9
Abstract: Bone morphogenetic proteins (BMPs) regulate many processes in the embryo, including cell type specification, patterning, apoptosis, and epithelial-mesenchymal interaction. They also act in soft and hard tissues in adult life. Their signals are transduced from the plasma membrane to the nucleus through a limited number of Smad proteins. The list of Smad-interacting proteins is however growing and it is clear that these partners determine the outcome of the signal. We summarize the present status in BMP/Smad signaling, with emphasis on recently identified Smad partners and how these proteins may cooperate in the regulation of the expression of BMP target genes.
ISSN: 0014-5793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Biology (Celgen) (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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