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Title: Translocation (Y;1)(q12;q12) in hematologic malignancies. Report on two new cases, FISH characterization, and review of the literature
Authors: Michaux, Lucienne ×
Wlodarska, Iwona
Vellosa, E R
Verhoef, Gregor
Van Orshoven, Angeline
Michaux, J L
Scheiff, J M
Mecucci, Christina
Van den Berghe, Herman #
Issue Date: Jun-1996
Series Title: Cancer genetics and cytogenetics. vol:86 issue:1 pages:35-8
Abstract: Translocation (Y;1)(q12;q12) is a rare cytogenetic anomaly occurring in hematologic disorders thought to affect stem cells. We report here on two new cases, one end-stage myelofibrosis and one chronic myelomonocytic leukemia. The translocation breakpoints were assessed by conventional cytogenetic techniques in both cases and by FISH in the second case. A partial trisomy of the 1q21-qter region could be demonstrated. The data of the literature are reviewed and the possible pathogenetic mechanisms are discussed.
ISSN: 0165-4608
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
Hematology Section (-)
Laboratory for Genetics of Malignant Disorders
Clinical Genetics
× corresponding author
# (joint) last author

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