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Title: Establishment of a mouse gastrointestinal stromal tumour model and evaluation of response to imatinib by small animal positron emission tomography
Authors: Prenen, Hans ×
Deroose, Christophe
Vermaelen, Peter
Sciot, Raphael
Debiec-Rychter, Maria
Stroobants, Sigrid
Mortelmans, Luc
Schöffski, Patrick
Van Oosterom, Allan #
Issue Date: Mar-2006
Publisher: Potamitis Press
Series Title: Anticancer Research vol:26 issue:2A pages:1247-1252
Abstract: BACKGROUND: Gastrointestinal stromal tumours (GIST) predominantly express activating mutations of the KIT tyrosine kinase receptor and are successfully treated with imatinib mesylate, a KIT inhibitor. As resistance to imatinib causes therapy failure, our aim was to develop an in vivo GIST model to evaluate KIT inhibitors and monitor therapy with small animal positron emission tomography (PET). MATERIALS AND METHODS: The first mouse model of GIST xenografts was successfully established by injecting GIST882 cells subcutaneously into nude mice. RESULTS: Using the small animal PET, FDG up-take in xenografts was significantly decreased after 24 h of treatment with imatinib, which correlated with a response to treatment, e.g., with a decrease in tumour volume, the inhibition of KIT and downstream intermediate phosphorylation and arrest of tumour cell proliferation as evaluated after 7 days of treatment. CONCLUSION: This model is useful to study imatinib resistance and to evaluate novel targeted therapies.
ISSN: 0250-7005
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Nuclear Medicine & Molecular Imaging
Clinical Genetics Section (-)
Laboratory of Experimental Oncology
Department of Oncology - miscellaneous
Translational Cell & Tissue Research
Laboratory for Genetics of Malignant Disorders
Clinical Digestive Oncology (+)
× corresponding author
# (joint) last author

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