Bulletin européen de physiopathologie respiratoire. vol:12 issue:2 pages:285-95
Experiments in rats during acute and prolonged periods of hypercapnia show important changes in the glutamate and glutamine content of the brain. Compartmentation studies using labelled glutamate intracisternally injected show an increased turnover of the small glutamate compartment. The possible pathophysiological significance of these observations is discussed.