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Title: Lhermitte-Duclos disease: 11C-methionine positron emission tomography data in 4 patients
Authors: Van Calenbergh, Frank ×
Vantomme, Nikolaas
Flamen, Patrick
Demaerel, Philippe
Sciot, Raphael
Legius, Eric
Mortelmans, Luc
Plets, Christian #
Issue Date: Mar-2006
Publisher: Elsevier Biomedical
Series Title: Surgical Neurology vol:65 issue:3 pages:293-297
Abstract: BACKGROUND: Lhermitte-Duclos disease is a cerebellar lesion, characterized by an overgrowth of cerebellar ganglion cells, which replace granular cells and Purkinje cells. Lhermitte-Duclos disease may be a manifestation of Cowden syndrome (multiple hamartoma-neoplasia syndrome). The nature of LDD, whether neoplastic, dysplastic, or hamartomatous, is still not exactly understood. Metabolic imaging of the amino acid metabolism using PET could be useful for noninvasive characterization of these lesions. METHODS: To define the Meth-PET imaging characteristics of these lesions, we undertook a Meth-PET study in 4 patients with LDD after obtaining informed consent. All 4 patients had clinical signs of Cowden syndrome. In 2, the diagnosis was made with MRI; in 2, it was confirmed histologically. RESULTS: Using Meth-PET, the cerebellar lesions had a high methionine uptake, except in the subtotally resected lesion. The uptake of the lesions was markedly higher than that of the contralateral normal regions. The mean L/C ratio was 2.07. CONCLUSION: 11C-methionine positron emission tomography visualizes the lesion of Lhermitte-Duclos disease as a high uptake area. This amino acid hypermetabolism may be related to the slow growth of the lesions, and is an argument to suggest that patients with LDD should be followed up carefully to detect progression of the cerebellar lesion.
ISSN: 0090-3019
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Nuclear Medicine & Molecular Imaging
Research Group Experimental Neurosurgery and Neuroanatomy
Clinical Residents Medicine
Clinical Genetics Section (-)
Translational Cell & Tissue Research
Translational MRI (+)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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