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Title: Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family
Authors: Veugelers, Mark
Vermeesch, Joris
Reekmans, Gunter
Steinfeld, Robert
Marynen, Peter
David, Guido # ×
Issue Date: Jun-1997
Series Title: Genomics. vol:40 issue:1 pages:24-30
Abstract: The four vertebrate glypican-related integral membrane proteoglycans identified so far constitute a discrete family of heparan sulfate proteoglycans that are linked to the cell surface via glycosyl phosphatidylinositol. In addition to the GPI anchor and substitution with heparan sulfate, the members of this family show significant sequence homology and share a unique and characteristic cysteine motif. Starting from an EST entry that showed significant sequence similarity to MXR7 and OCI-5 (coding, respectively, for human and rat glypican-3), we have isolated a human cDNA coding for glypican-5, a novel member of this proteoglycan family. The gene for this novel glypican (GPC5) maps to 13q32. In the adult, it is primarily expressed in brain tissue.
ISSN: 0888-7543
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Genetics Section (-)
Clinical Genetics Section (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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