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Title: Translocation of the HMGI-C ( HMGA2) gene in a benign mesenchymoma (chondrolipoangioma)
Authors: Van Dorpe, Jo ×
Dal Cin, Paola
Weremowicz, Stanislawa
Van Leuven, Freddy
De Wever, Ivo
Van den Berghe, Herman
Fletcher, Christopher D M
Sciot, Raphael #
Issue Date: May-2002
Series Title: Virchows Archiv vol:440 issue:5 pages:485-90
Abstract: Mesenchymomas are neoplasms in which there are at least two types of differentiated cells of mesenchymal derivation other than fibrous tissue. Chondrolipoangioma is a rare type of mesenchymoma composed predominantly of cartilage and adipose tissue with vascular elements and myxoid tissue present in lesser proportions. Cytogenetic analysis was performed on a case of chondrolipoangioma and revealed a t(12;15) (q13;q26) as the sole chromosome abnormality in 40 metaphases analyzed. However, using fluorescence in situ hybridization (FISH) analysis, a complex rearrangement was found involving chromosomes 2, 12, and 15, with a cryptic rearrangement of the gene ( HMGI-C; HMGA2) coding for high-mobility group I protein. This finding suggests a role for the HMGI-C gene also in the pathogenesis of this uncommon benign tumor type, in addition to its well-established role in the pathogenesis of common benign tumors such as lipomas, uterine leiomyomas, pulmonary chondroid hamartomas, and endometrial polyps.
ISSN: 0945-6317
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Surgical Oncology
Associated Laboratories - miscellaneous (-)
Clinical Genetics Section (-)
Department of Human Genetics - miscellaneous
Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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