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Title: Birth weight and body composition in young women: a prospective twin study
Authors: Loos, Ruth
Beunen, Gaston
Fagard, Robert
Derom, Cathérine ×
Vlietinck, Robert #
Issue Date: 2002
Series Title: The American Journal of Clinical Nutrition. vol:75 issue:4 pages:676-82
Abstract: BACKGROUND: The intrauterine environment may be critical for the development of obesity. Alternatively, the same genetic factors may influence both birth weight and adult body composition. OBJECTIVE: We evaluated the association between birth weight and adult body composition in female twins, which allowed us to control for maternal and genetic influences. DESIGN: Of 447 twin pairs randomly selected from the East Flanders Prospective Twin Survey, 238 pairs, aged 18-34 y, participated. Adult body mass, height, and lean body mass were measured, and the body mass index (BMI), waist-to-hip ratio, and sum of skinfold thicknesses were calculated. The twins were considered as individuals and pairs. RESULTS: When the twins were considered as individuals, twins who were heavier at birth were taller (3.3 cm/kg greater birth weight) and slightly heavier (1.13 kg/kg greater birth weight) as adults than were lighter twins. They also had more lean body mass and less subcutaneous and abdominal fat at birth. Pairwise comparison showed that for every level of intrapair birth weight difference (> or = 5%, > or = 10%, and > or = 15%), the twin who was heavier at birth was taller in adult life (0.8, 1.2, and 2.0 cm, respectively). When the intrapair birth weight difference exceeded 15%, the heavier twin was also heavier (3.1 +/- 6.08 kg) as an adult than her much lighter sister. CONCLUSION: Birth weight accounts for some of the differences in adult body composition between twins.
ISSN: 0002-9165
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Exercise Physiology Research Group
Clinical Genetics Section (-)
Hypertension and Cardiovascular Epidemiology
Department of Human Genetics - miscellaneous
Department of Kinesiology - miscellaneous
Physical Activity, Sports & Health Research Group
× corresponding author
# (joint) last author

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