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Title: Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain size in transgenic mice
Authors: Spittaels, K ×
Van Den Haute, Chris
Van Dorpe, Jo
Terwel, Dirk
Vandezande, K
Lasrado, Reena
Bruynseels, K
Irizarry, M
Verhoye, M
Van Lint, Johan
Vandenheede, Jackie
Ashton, D
Mercken, Marc
Loos, R
Hyman, B
Van der Linden, A
Geerts, H
Van Leuven, Freddy #
Issue Date: Aug-2002
Publisher: Pergamon Press
Series Title: Neuroscience vol:113 issue:4 pages:797-808
Abstract: Glycogen synthase kinase-3beta (GSK-3beta) is important in neurogenesis. Here we demonstrate that the kinase influenced post-natal maturation and differentiation of neurons in vivo in transgenic mice that overexpress a constitutively active GSK-3beta[S9A]. Magnetic resonance imaging revealed a reduced volume of the entire brain, concordant with a nearly 20% reduction in wet brain weight. The reduced volume was most prominent for the cerebral cortex, without however, disturbing the normal cortical layering. The resulting compacted architecture was further demonstrated by an increased neuronal density, by reduced size of neuronal cell bodies and of the somatodendritic compartment of pyramidal neurons in the cortex. No evidence for apoptosis was obtained. The marked overall reduction in the level of the microtubule-associated protein 2 in brain and in spinal cord, did not affect the ultrastructure of the microtubular cytoskeleton in the proximal apical dendrites. The overall reduction in size of the entire CNS induced by constitutive active GSK-3beta caused only very subtle changes in the psychomotoric ability of adult and ageing GSK-3beta transgenic mice.
ISSN: 0306-4522
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group for Neurobiology and Gene Therapy
Department of Human Genetics - miscellaneous
Biochemistry Section (Medicine) (-)
Associated Laboratories - miscellaneous (-)
Laboratory of Protein Phosphorylation and Proteomics
× corresponding author
# (joint) last author

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