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Title: del(7q) in chronic B-cell lymphoid malignancies
Authors: Hernandez, J M ×
Mecucci, Christina
Michaux, Lucienne
Criel, Arnold
Stul, Michel
Meeus, Peter
Wlodarska, Iwona
Van Orshoven, Angeline
Cassiman, Jean-Jacques
Peeters, Christiane
Van den Berghe, Herman #
Issue Date: Apr-1997
Series Title: Cancer genetics and cytogenetics. vol:93 issue:2 pages:147-51
Abstract: Twelve patients with diagnosis of B-cell non-Hodgkin's lymphoma/leukemia and del[7q] were studied for their clinical, cytogenetic, and molecular characteristics. Eleven patients were classified as small cell lymphoma whereas one had a diffuse large cell lymphoma. Lymphoplasmacytic features were observed in six out of eleven small cell lymphomas. Morphologically and immunologically these small cell lymphomas could be classified as chronic lymphocytic leukemia (typical or atypical; 4 cases), marginal zone lymphoma (splenic lymphoma with villous lymphocytes; 1 case), mantle cell lymphoma (2 cases), or nonspecified, non-Hodgkin's lymphoma (4 cases). Eleven of twelve patients presented with peripheral blood and bone marrow involvement. Two of twelve cases showed del[7q] as the sole anomaly. Two different types of deletions were present: ten cases had del(7)(q21q31) and two cases had del(7)(q31q34). Cases that could be molecularly investigated did not show any involvement of BCL2, BCL3, or BCL6, and only one case had BCL1 rearrangement. The data indicate that del(7q) is associated with a subset of mature small B-cell lymphoproliferative disorders of which some but not all show lymphoplasmatic features.
URI: 
ISSN: 0165-4608
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
Human Mutations and Polymorphisms Section (-)
Forensic Biomedical Sciences
Laboratory for Genetics of Malignant Disorders
Clinical Genetics
Medicine Teaching Programs
× corresponding author
# (joint) last author

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