Title: Does occupational exposure to PAHs, diesel and aromatic amines interact with smoking and metabolic genetic polymorphisms to increase the risk on bladder cancer?; The Belgian case control study on bladder cancer risk
Authors: Kellen, Eliane ×
Zeegers, Maurice
Paulussen, Aimée
Vlietinck, Robert
Vlem, Eddy Van
Veulemans, Hendrik
Buntinx, Frank
Paulussen, A
Vlem, EV #
Issue Date: Jan-2007
Publisher: Elsevier
Series Title: Cancer letters vol:245 issue:1-2 pages:51-60
Abstract: To investigate the association between occupational exposure to polycyclic aromatic hydrocarbons, aromatic amines and diesel and bladder cancer risk and the modification by smoking and metabolic polymorphisms, have we recruited 200 cases and 385 population controls. The adjusted OR of bladder cancer was 5.75 (95%CI 2.09-15.83) comparing the highest tertile of the cumulative probability of occupational exposure to aromatic amines with no occupational exposure. A possible interaction between occupational exposures to aromatic amines and smoking was found. The increased ORs of GSTM1, GSTT1, NAT2 and SULT1A1 among those ever occupational exposed was explored by estimating the false-positive report probability. We confirm that occupational exposure to aromatic amines is associated with an increase in bladder cancer risk.
ISSN: 0304-3835
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Center for General Practice
Clinical Genetics Section (-)
Environment and Health - miscellaneous
Occupational, Environmental and Insurance Medicine (-)
× corresponding author
# (joint) last author

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