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Title: Synaptopodin and 4 novel genes identified in primary sensory neurons
Authors: Verpoorten, Nathalie ×
Verhoeven, Kristien
Weckx, Stefan
Jacobs, An
Serneels, Sally
Del Favero, Jurgen
Ceuterick, Chantal
Van Bockstaele, Dirk R
Berneman, Zwi N
Van Den Bosch, Ludo
Robberecht, Wim
Nobbio, Lucilla
Schenone, Angelo
Dessaud, Eric
deLapeyrière, Odile
Huylebroeck, Danny
Zwijsen, An
De Jonghe, Peter
Timmerman, Vincent #
Issue Date: Nov-2005
Publisher: Academic Press
Series Title: Molecular and Cellular Neurosciences vol:30 issue:3 pages:316-325
Abstract: We performed differential gene expression profiling in the peripheral nervous system by comparing the transcriptome of sensory neurons with the transcriptome of lower motor neurons. Using suppression subtractive cDNA hybridization, we identified 5 anonymous transcripts with a predominant expression in sensory neurons. We determined the gene structures and predicted the functional protein domains. The 4930579P15Rik gene encodes for a novel inhibitor of protein phosphatase-1 and 9030217H17Rik was found to be the mouse gene synaptopodin. We performed in situ hybridization for all genes in mouse embryos, and found expression predominantly in the primary class of sensory neurons. Expression of 4930579P15Rik and synaptopodin was restricted to craniospinal sensory ganglia. Neither synaptopodin, nor any known family member of 4930579P15Rik, has ever been described in sensory neurons. The identification of protein domains and expression patterns allows further functional analysis of these novel genes in relation to the development and biology of sensory neurons.
URI: 
ISSN: 1044-7431
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Biology (Celgen) (-)
Research Group Experimental Neurology
Laboratory for Neurobiology (Vesalius Research Center)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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