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Title: ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma
Authors: De Paepe, Pascale ×
Baens, Thijs
van Krieken, Han
Verhasselt, Bruno
Stul, Michel
Simons, Annet
Poppe, Bruce
Laureys, Geneviève
Brons, Paul
Vandenberghe, Peter
Speleman, Frank
Praet, Marleen
Peeters, Christiane
Marynen, Peter
Wlodarska, Iwona #
Issue Date: Sep-2003
Series Title: Blood vol:102 issue:7 pages:2638-41
Abstract: We present 3 cases of large B-cell lymphoma (LBCL) with a granular cytoplasmic staining for anaplastic lymphoma kinase (ALK). All of the cases showed striking similarities in morphology and immunohistochemical profile characterized by a massive monomorphic proliferation of CD20-/CD138+ plasmablast-like cells. In one of the cases, initially diagnosed as a null-type anaplastic large cell lymphoma (ALCL), the B-cell phenotype became evident only at recurrence. Fluorescent in situ hybridization (FISH) and molecular studies led to the detection of a CLTC-ALK rearrangement in all 3 cases, without any evidence of full-length ALK receptor expression. The associated t(2;17)(p23;q23) was demonstrated in the karyotype of 2 cases. Although a similar CLTC-ALK aberration was previously identified in ALK-positive T-/null cell ALCL and inflammatory myofibroblastic tumor, its association with ALK-positive LBCL seems to be specific and intriguing.
URI: 
ISSN: 0006-4971
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Genetics Section (-)
Clinical Genetics Section (-)
Translational Cell & Tissue Research
Human Genome Laboratory
Laboratory for Genetics of Malignant Disorders
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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