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Title: Cytogenetic and fluorescence in situ hybridization investigation of ring chromosomes characterizing a specific pathologic subgroup of adipose tissue tumors
Authors: Dal Cin, Paola ×
Kools, Patrick
Sciot, Raphael
De Wever, Ivo
Van Damme, Boudewijn
Van de Ven, Willem
Van den Berghe, Herman #
Issue Date: Sep-1993
Publisher: Elsevier Science Pub. Co.
Series Title: Cancer Genetics and Cytogenetics vol:68 issue:2 pages:85-90
Abstract: Cytogenetic analysis of 184 adipose tissue tumors, 175 lipomas, and nine liposarcomas (LPS) showed the presence of a ring chromosome and/or a long marker chromosome in 10 cases with common histologic features such as atypical stromal cells with or without lipoblasts. In five of the cases, this appeared to be the sole cytogenetic abnormality. Fluorescence in situ hybridization (FISH) analysis with a microclone library specific for chromosome region 12q13-q15 showed extensive staining of the ring and long marker chromosomes, indicating that genetic sequences of this particular region of chromosome 12 are present in these marker chromosomes, most likely in an amplified form.
ISSN: 0165-4608
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Surgical Oncology
Clinical Genetics Section (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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