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Title: Small B cell NHL and their leukemic counterpart: differences in subtyping and assessment of leukemic spread
Authors: Criel, Arnold ×
Pittaluga, Stefania
Verhoef, Gregor
Wlodarska, Iwona
Meeus, Peter
Mecucci, Christina
Van Orshoven, Angeline
Van den Berghe, Herman
Boogaerts, Marc
Peeters, Christiane #
Issue Date: Jul-1996
Series Title: Leukemia vol:10 issue:5 pages:848-53
Abstract: Three subtypes of small lymphocytic lymphoma were studied, namely B cell chronic lymphocytic leukemia (B-CLL), mantle cell lymphoma (MCL) and follicle center lymphoma (FCL). Agreement between tissue diagnosis, based on the proposal for a revised European-American classification of lymphoid neoplasms from the International Lymphoma Study Group, and the cytomorphological diagnosis on peripheral blood and/or bone marrow smears, using the proposals for the classification of chronic (mature) B and T lymphoid leukemias of the French-American-British Cooperative Group, was studied. Full agreement was found in 90% of the CLL and 82% of the FCL cases. In MCL cases, agreement was 65% including all cases classified as intermediate/mantle zone lymphoma according to FAB criteria. The incidence of bone marrow involvement detection in trephines compared to smears was equal in CLL (both 100%) and slightly higher in MCL (56 vs 48.5%); in FCL, however, trephine biopsies provided more reliable material (71 vs 35%).
ISSN: 0887-6924
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hematology Section (-)
Clinical Genetics Section (-)
Laboratory for Genetics of Malignant Disorders
Clinical Genetics
Medicine Teaching Programs
× corresponding author
# (joint) last author

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