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Title: Distribution of the beta 1 subgroup of the integrins in human cells and tissues
Authors: De Strooper, Bart
Van der Schueren, Bernadette
Jaspers, M
Saison, Marc
Spaepen, M
Van Leuven, Freddy
Van den Berghe, Herman
Cassiman, Jean-Jacques #
Issue Date: Mar-1989
Series Title: Journal of Histochemistry & Cytochemistry vol:37 issue:3 pages:299-307
Abstract: We studied the distribution of the beta 1 integrin subfamily in human tissues and cells by light microscopy, electron microscopy, and immunoblotting, using monoclonal antibody DH12, previously shown to react with the beta 1 subunit of the human fibronectin receptor. Crossreaction with the other beta subunits of the integrin family, which have 45% and 47% primary amino acid sequence identity with the beta 1 subunit, was excluded, as MAb DH12 did not react with the beta 2 subunit in granulocytes and the beta 3 subunit in thrombocytes. Reactivity with the anti-beta 1 antibody was found in skin, lung, heart, striated and smooth muscle, blood cells, liver, kidney, intestine, spleen and placenta. Thus, cells of mesodermal, ectodermal, and entodermal origin express the beta 1 subunit. In skin fibroblasts cultured in vitro, beta 1 subunit was also detected intracellularly. The wide distribution of the beta 1 family, originally detected in activated T-lymphocytes after prolonged culture in vitro, contrast with the restricted distribution of the beta 2 integrins on leucocytes.
ISSN: 0022-1554
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Genetics Section (-)
Associated Laboratories - miscellaneous (-)
Human Mutations and Polymorphisms Section (-)
Clinical Genetics Section (-)
Forensic Biomedical Sciences
Department of Human Genetics - miscellaneous
# (joint) last author

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