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Title: Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins
Authors: Annaert, Wim ×
Esselens, Carl
Baert, Veerle
Boeve, Christine
Snellings, Greet
Cupers, Philippe
Craessaerts, Kathleen
De Strooper, Bart #
Issue Date: Nov-2001
Series Title: Neuron. vol:32 issue:4 pages:579-89
Abstract: The carboxyl terminus of presenilin 1 and 2 (PS1 and PS2) binds to the neuron-specific cell adhesion molecule telencephalin (TLN) in the brain. PS1 deficiency results in the abnormal accumulation of TLN in a yet unidentified intracellular compartment. The first transmembrane domain and carboxyl terminus of PS1 form a binding pocket with the transmembrane domain of TLN. Remarkably, APP binds to the same regions via part of its transmembrane domain encompassing the critical residues mutated in familial Alzheimer's disease. Our data surprisingly indicate a spatial dissociation between the binding site and the proposed catalytic site near the critical aspartates in PSs. They provide important experimental evidence to support a ring structure model for PS.
ISSN: 0896-6273
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Genetics Section (-)
Laboratory of Membrane Trafficking
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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