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Title: Trisomy 12 is uncommon in typical chronic lymphocytic leukaemias
Authors: Criel, Arnold ×
Wlodarska, Iwona
Meeus, Peter
Stul, Michel
Louwagie, Andries
Van Hoof, Achilles
Hidajat, M
Mecucci, Christina
Van den Berghe, Herman #
Issue Date: Jan-1995
Series Title: British Journal of Haematology vol:87 issue:3 pages:523-8
Abstract: The incidence of trisomy 12 was studied by conventional chromosome analysis in 111 patients referred as B-cell chronic lymphocytic leukaemia (B-CLL). Fluorescent in situ hybridization (FISH) was also applied in 34 of those patients with either a normal karyotype or no analysable mitoses. By karyotyping, trisomy 12 was present in 11.7% (13/111), whereas additional FISH increased the incidence to 14.4% (16/111). When subdividing our cases in either typical CLL (n = 90), fulfilling the FAB classification criteria, or atypical CLL (n = 21), with one or more variations from those criteria, the incidence of +12 by metaphase analysis was 3% and 48%, respectively. Additional FISH increased the incidence to 4% and 57%. The most common aberration in atypical CLL was FMC7 positivity (n = 11), followed by CD5 negativity (n = 8), strong surface immunoglobulin staining (n = 7) and atypical morphology (n = 6). Trisomy 12 could only be demonstrated in a small proportion of neoplastic cells in all positive cases. By FISH and/or karyotyping, all available samples at diagnosis of the disease were positive.
ISSN: 0007-1048
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
Laboratory for Genetics of Malignant Disorders
Clinical Genetics
Medicine Teaching Programs
× corresponding author
# (joint) last author

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