Title: Cytokeratin-positive meningeal peripheral PNET/Ewing's sarcoma of the cervical spinal cord: diagnostic value of genetic analysis
Authors: Woestenborghs, Heidi ×
Debiec-Rychter, Maria
Renard, Marleen
Demaerel, Philippe
Van Calenbergh, Frank
Van Gool, Stefaan
Sciot, Raphael #
Issue Date: Jan-2005
Publisher: Churchill Livingstone
Series Title: International Journal of Surgical Pathology vol:13 issue:1 pages:93-97
Abstract: Peripheral primitive neuroectodermal tumor (PNET)/Ewing's sarcoma (ES) of the central nervous system is extremely rare and should be differentiated from central PNET and other small blue round cell tumors. We describe a case of a meningeal peripheral PNET/ES of the spinal cord in an 11-year-old boy. Immunohistochemically, the small blue round cell tumor showed expression of epithelial markers and of CD99, thus posing an important differential diagnostic problem with a poorly differentiated synovial sarcoma. Fluorescence in situ hybridization revealed rearrangement of the EWS gene, as seen in peripheral PNET/ES. Peripheral PNET/ES does occur in the central nervous system, but its diagnosis can be extremely difficult on morphologic and immunohistochemical grounds alone. Genetic analysis plays a key role in its distinction from other small blue round cell tumors.
ISSN: 1066-8969
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
Research Group Experimental Neurosurgery and Neuroanatomy
Laboratory of Clinical Immunology
Translational Cell & Tissue Research
Laboratory of Pediatric Immunology
Translational MRI (+)
Laboratory for Genetics of Malignant Disorders
× corresponding author
# (joint) last author

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