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Title: An inv(16)(p13q22) positive acute myeloid leukaemia relapsing as acute precursor B-cell lymphoblastic leukaemia
Authors: Boeckx, Nancy ×
van der Velden, Vincent H J
Boogaerts, Marc
Hagemeijer-Hausman, Anne
Vandenberghe, Peter
van Dongen, Jacques J M #
Issue Date: Sep-2004
Series Title: Haematologica vol:89 issue:8 pages:ECR28
Abstract: We describe a case of a 38-year old male with inv(16)(p13q22) positive acute myeloid leukaemia (AML) with eosinophilia, relapsing after a molecular remission of almost three years. Remarkably, the leukaemia at relapse was identified as a precursor-B-cell acute lymphoblastic leukaemia (B-ALL) by cytology and immunophenotyping, but was inv(16)(p13q22) positive as revealed by interphase FISH, FICTION analysis, and real-time quantitative PCR. Analysis of immunoglobulin and T-cell receptor genes showed a bi-allelic DH2-JH rearrangement at relapse, but not at diagnosis. These findings indicate a myeloid to lymphoid lineage switch from an inv(16)(p13q22) positive leukaemia and show that IGH gene rearrangements can occur in the presence of CBFB-MYH11 fusion transcripts.
URI: 
ISSN: 0390-6078
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hematology Section (-)
Clinical Genetics Section (-)
Laboratory of Clinical Bacteriology and Mycology
Department of Oncology - miscellaneous
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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