Title: The role of vitamin D in the pathogenesis of NOD mouse diabetes
Authors: Gysemans, Conny ×
Decallonne, Brigitte
van Etten, Evelyne
Mathieu, Chantal #
Issue Date: Jul-2007
Publisher: Bentham Science Publishers
Series Title: Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry vol:7 issue:3 pages:203-209
Abstract: The existence of ß-cell dysfunction and insulin resistance in vitamin D-deficient individuals on top of the demonstrated presence of receptors for 1,25-dihydroxyvitamin D3, the active metabolite of vitamin D, in pancreatic islet ß-cells and immune cells have lead to scientific and clinical interest in vitamin D with respect to its potential role in the pathogenesis of type 1 diabetes. Also, its therapeutic potential in the prevention of type 1 diabetes has been studied, especially since the availability of synthetic analogues of the molecule that lack its calcemic effects. Solid evidence is available on the detrimental effects of vitamin D deficiency on insulin synthesis and secretion in animal models as well as in humans. Interventions with pharmacological doses of 1,25-dihydroxyvitamin D3 are able to delay onset of autoimmune diabetes in NOD mice mainly through immune modulation.
ISSN: 1871-5222
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
Medical Clerkships Centers
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.