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Title: The karyotype in secondary hematologic disorders after treatment for Hodgkin's disease. A study of 19 patients
Authors: Iurlo, A ×
Mecucci, Christina
Van Orshoven, Angeline
Michaux, J L
Boogaerts, Marc
Van den Berghe, Herman #
Issue Date: Feb-1989
Series Title: Cancer genetics and cytogenetics. vol:36 issue:2 pages:165-72
Abstract: In 19 cases of secondary hematologic disorders in patients previously treated for Hodgkin's disease, chromosome aberrations were analyzed in relation to the type of previous chemo- and/or radiotherapy, age of the patients, histopathologic features of the Hodgkin's disease at diagnosis, time interval between the treatment and the occurrence of the secondary disorder, and survival. The karyotype was of significant prognostic value when three cytogenetic groups were considered: patients with normal karyotypes; patients with aberrations of chromosome 7 as the sole anomaly; and patients with complex rearrangements and translocations. The last group showed the lowest rate of survival. Bone marrow transplantation was successful in two patients with a normal karyotype.
ISSN: 0165-4608
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hematology Section (-)
Clinical Genetics Section (-)
Clinical Genetics
× corresponding author
# (joint) last author

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