Title: Determination of boron in human serum by inductively-coupled plasma-mass spectrometry after a simple dilution of the sample
Authors: Vanhoe, H ×
Dams, R
Vandecasteele, Carlo
Versieck, J #
Issue Date: Sep-1993
Publisher: Elsevier science bv
Series Title: Analytica chimica acta vol:281 issue:2 pages:401-411
Abstract: A method for the determination of boron in human serum is described. Serum samples were only treated with 0.14 M HNO3 (a five-fold dilution). After addition of beryllium as internal standard to correct for matrix effects, samples were introduced with a concentric nebulizer to an inductively coupled plasma mass spectrometer. The magnitude of the boron ion signal was optimized by adjusting the lens voltages and the nebulizer gas flow rate and memory effects, which can be experienced with the conventional methodology for sample introduction, were reduced to an acceptable level by the use of a short (2 min) cleanout procedure. To avoid the overlap from the intense C-12+-peak with the B-11+-peak, the B-10+-peak was used for the boron determinations. This procedure gave a boron blank level of about 1.7 mug l-1 and a detection limit of 0.5 mug l-1 for human serum. External calibration was applied for the quantitation of boron. The proposed method was tested by analysing a ''second-generation'' biological reference material Freeze-Dried Human Serum (University of Ghent). Results are also given for three other biological reference materials, namely Wheat Flour SRM 1567a, Bovine Liver SRM 1577a and Total Diet SRM 1548 (National Institute of Standards and Technology). Analyses of serum samples from twelve healthy individuals yielded boron concentrations ranging from 4.1 to 25.8 gg l-1.
ISSN: 0003-2670
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Process Engineering for Sustainable Systems Section
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science