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Title: t(1;19) without detectable E2A rearrangements in two t(14;18)-positive lymphoma/leukemia cases
Authors: Wlodarska, Iwona ×
Stul, Michel
Peeters, Christiane
Verhoef, Gregor
Mecucci, Christina
Cassiman, Jean-Jacques
Van den Berghe, Herman #
Issue Date: Oct-1994
Series Title: Genes, chromosomes & cancer. vol:10 issue:3 pages:171-6
Abstract: Translocation t(1;19)(q23;p13) plays a crucial role in the pathogenesis of childhood pre-B cell leukemia and results in the formation of a fusion gene E2A-PBX1 that encodes a hybrid transcription factor with oncogenic potential. Here we describe two cases, one follicular lymphoma and one acute lymphoblastic leukemia/lymphoma, characterized by a complex karyotype including t(14;18), t(8;14), as well as t(1;19). Molecular studies in both cases failed to show rearrangements of the E2A gene. These results suggest that the t(1;19) found as a secondary chromosome change in t(14;18)-positive lymphoma/leukemia might be a molecular variant of the t(1;19) that is typical of childhood pre-B cell leukemia.
ISSN: 1045-2257
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics
Laboratory for Genetics of Malignant Disorders
Forensic Biomedical Sciences
Clinical Genetics Section (-)
Hematology Section (-)
Human Mutations and Polymorphisms Section (-)
× corresponding author
# (joint) last author

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