Antibody immunoconjugates and radiopharmaceuticals vol:6 issue:4 pages:257-266
True local hyperthermia (HT) is difficult to realize in small animal models. A new procedure was set up to use a gel heated by the well-monitored heating antennas of a clinical hyperthermia machine (Minerve(R)) to avoid general heating of the mice by the steam. This procedure allows heating of six tumors (six animals) at the same time. The temperature can be individually adjusted at any time, taking into account the tumor size, the variations of the biological conditions and some direct warming effects of the electrical currents. This practical set-up was used to study the effect of local hyperthermia on tumor targeting by radiolabeled antibodies.