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Title: Microdissection and FISH investigations in acute myeloid leukemia: a step forward to full identification of complex karyotypic changes
Authors: Falzetti, D ×
Vermeesch, Joris
Matteucci, C
Ciolli, S
Martelli, M F
Marynen, Peter
Mecucci, Christina #
Issue Date: Apr-2000
Publisher: Elsevier Science Pub. Co.
Series Title: Cancer Genetics and Cytogenetics vol:118 issue:1 pages:28-34
Abstract: Complex chromosomal rearrangements in malignant hemopathies frequently remain unclarified because of paucity of material for further fluorescence in situ hybridization analyses and/or lack of suitable probes. Chromosome microdissection (MD) can be an adequate approach to elucidate chromosome aberrations unrecognizable by conventional karyotyping. We applied MD in two patients with acute myeloid leukemia (AML) and unidentified chromosome changes at karyotype. Microdissection of a ring chromosome in an AML-M5 case revealed 21q polysomy. In an AML-M4 case, MD of an add(15p) disclosed a t(8;15) with over-representation of both 8q22 and 8q24 bands. YAC probes were helpful in showing duplication of the ETO gene at 8q22, and amplification of C-MYC, at 8q24.
ISSN: 0165-4608
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Genetics Section (-)
Clinical Genetics Section (-)
Clinical Genetics
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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