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Title: Analysis of the P53, RB/D13S25, and P16 tumor suppressor genes in marginal zone B-cell lymphoma: An interphase fluorescence in situ hybridization study
Authors: Dierlamm, J ×
Stefanova, M
Wlodarska, Iwona
Hinz, K
Maes, B
Michaux, Lucienne
Stul, Michel
Verhoef, Gregor
Thomas, José
Peeters, Christiane
Van den Berghe, Herman
Hossfeld, D K
Hagemeijer-Hausman, Anne #
Issue Date: Aug-2000
Series Title: Cancer genetics and cytogenetics. vol:120 issue:1 pages:1-5
Abstract: The genetic mechanisms underlying the genesis, disease progression, and high-grade transformation of marginal zone B-cell lymphoma (MZBCL) are poorly understood. We analyzed 33 cases of histologically and immunophenotypically well-characterized MZBCL (12 extranodal, 11 nodal, and 10 splenic MZBCL; 27 at primary diagnosis and six during the course of disease) by dual-color interphase fluorescence in situ hybridization (FISH) for deletions of tumor suppressor genes. We investigated loci known to play a role in the genesis or disease progression of other subtypes of lymphoid malignancies, namely the P53 gene (17p13), the retinoblastoma gene (RB, 13q14), the D13S25 locus (13q14), and the P16(INK4A) gene (9p21). Heterozygous deletions of P53 were detected in three out of the 33 cases, including two splenic and one extranodal MZBCL. One of these patients was analyzed at primary diagnosis and two during the course of disease. Heterozygous deletions of the RB gene (nodal MZBCL) and D13S25 (splenic MZBCL) were found in one case each. P16 deletions were not detected in any of our cases. We conclude that deletions of the analyzed tumor suppressor genes are relatively rare in MZBCL, which contrasts with the findings in some other subtypes of NHL.
ISSN: 0165-4608
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
Laboratory of Nephrology
Hematology Section (-)
Department of Oncology - miscellaneous
Laboratory for Genetics of Malignant Disorders
× corresponding author
# (joint) last author

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