Title: Combinatorial expression of phenotypes of different cell lineages in the rat and mouse pituitary
Authors: Denef, Carl ×
Pals, Katrien
Hauspie, Annelies
Vankelecom, Hugo
Seuntjens, Eve #
Issue Date: May-2005
Publisher: New York Academy of Sciences
Series Title: Annals of the New York Academy of Sciences vol:1040 pages:84-88
Abstract: As studied by single cell RT-PCR of pituitary hormones, we demonstrated that the pituitaries of rats and mice contain a subpopulation of cells that express two or more hormone phenotypes typically belonging to lineages that are branched separately early during embryonic development, such as glycoprotein hormone alpha-subunit (alphaGSU) mRNA + PRL mRNA, alphaGSU mRNA + POMC mRNA, and POMC mRNA + GH or PRL mRNA. GnRH in vitro selectively expands the population of cells coexpressing alphaGSU mRNA + PRL mRNA, and CRH selectively increases the proportion of cells coexpressing alphaGSU mRNA + POMC mRNA. Colocalization of alphaGSU + PRL or alphaGSU + POMC could not be detected by double immunofluorescence. This lineage promiscuity was also observed in the pituitary in vivo.
ISSN: 0077-8923
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmacology Section (-)
Physiology Section (-)
Laboratory of Tissue Plasticity (-)
Embryo and Stemcells (-)
× corresponding author
# (joint) last author

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