Title: Structural and radiological parameters for the nondestructive characterization of trabecular bone
Authors: Pattijn, Veerle ×
Van Cleynenbreugel, Tim
Vander Sloten, Jos
Van Audekercke, Remy
Van der Perre, Georges
Wevers, Martine #
Issue Date: Dec-2001
Publisher: Blackwell Scientific Publications
Series Title: Annals of Biomedical Engineering vol:29 issue:12 pages:1064-1073
Abstract: Trabecular bone is characterized by compositional and organizational factors. The former include porosity at microlevel and mineralization. The latter refer to the trabecular architecture. Both determine the mechanical properties of the trabecular bone. The aim of this study is to investigate the relationship between the mechanical properties and the local HU value, the bone mineral density, the in vitro histomorphometric properties assessed by means of microcomputed tomography, and the Young's modulus determined by ultrasound measurement. Also the correlation between local HU values based on CT data of the full bone and HU values based on CT data of excised trabecular bone cylinders is investigated. Therefore density and strength related parameters of 22 trabecular bone cylinders retrieved from a fresh cadaver femur were measured by using different techniques. The mean HU value of the excised bone samples is very highly correlated with the pQCT density (R-2 =0.95) and the muCT-based morphometric parameter BV/TV (R-2 = 0.95). The mean HU values, determined from the CT images of the planned and excised bone samples, are less highly correlated (R-2 = 0.75). The Young's modulus E-US determined from the ultrasound measurement is highly correlated with the maximal stress sigma(max) (R-2 = 0.88) but not with the mechanically determined Young's modulus E-mech (R-2 = 0.67). The maximal stress sigma(max) correlates well with the density parameters (R-2 varies between 0.76 and 0.86). On the contrary the mechanically determined Young's modulus Em,,h does not correlate well with the density parameters (R2 varies between 0.52 and 0.56). The absorbed energy E-abs during the deformation is only highly correlated with the maximal stress sigma(max) (R-2 = 0.83). The inclusion of structural parameters besides a density related parameter did improve the prediction of the Young's modulus and the maximal stress. In conclusion, it seems that the HU value from clinical CT scanning is a good predictor of the local bone density and volume fraction. A combination of local density and a measure of the structural anisotropy is clearly needed to achieve good predictions of bone mechanics. (C) 2001 Biomedical Engineering Society.
ISSN: 0090-6964
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biomechanics Section
Mechanical Metallurgy Section (-)
× corresponding author
# (joint) last author

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