Title: Characterisation of antibiotic moenomycin A interaction with phospholipid model membranes
Authors: Volke, F ×
Waschipky, R
Pampel, A
Donnerstag, A
Lantzsch, G
Pfeiffer, Helge
Richter, W
Klose, G
Welzel, P #
Issue Date: Feb-1997
Publisher: Elsevier sci ireland ltd
Series Title: Chemistry and physics of lipids vol:85 issue:2 pages:115-123
Abstract: Using a combination of physico-chemical techniques (MAS NMR, DSC, freeze-fracture electron microscopy, molecular modelling) the antibiotic moenomycin A was found to be anchored by its hydrophobic chain into multilamellar POPC membranes. The lamellar phase structure of the modified membrane is retained, while moenomycin A in water at different concentrations does not form any other but isotropic phase structures. The mobility of POPC molecule segments is reduced with increasing moenomycin A concentrations. Freeze-fracture electron microscopy images show ripple like structures for low moenomycin A concentrations, which are rare for high concentrations. A sugar-group network of the antibiotic seems to cover the whole membrane surface for molar ratios moenomycin A/POPC of 1:2, which is supported by C-13-MAS (Magic Angle Spinning) NMR, P-31-NMR, and molecular modelling. (C) 1997 Elsevier Science Ireland Ltd.
ISSN: 0009-3084
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Materials Engineering - miscellaneous
× corresponding author
# (joint) last author

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