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Title: Ring chromosome 6 may represent a cytogenetic subgroup in benign thymoma
Authors: Van den Berghe, Ivo ×
Debiec-Rychter, Maria
Proot, Luc
Hagemeijer-Hausman, Anne
Michielssen, Paul #
Issue Date: Oct-2002
Series Title: Cancer genetics and cytogenetics. vol:137 issue:1 pages:75-7
Abstract: Cytogenetic and fluorescence in situ hybridization analysis of a thymoma revealed the presence of an abnormal clone with a karyotype 46,XY,r(6)(p2?q35?).ish r(6)(p2?q35?)(WCP6+,dJ476O18-,dJ62I11-, PAC59C23+,PAC57H24-),der(21)t(6;21)(p25;q22)(dJ62I11+,cosC9a1-). Histologically, the tumor was encapsulated and classified as thymoma type AB (World Health Organization classification) or mixed thymoma (Muller-Hermelink classification), composed of well-formed lobules with sharp demarcation of both the spindly type A and lymphocyte-rich type B components. This finding, together with literature data, strongly suggests that terminal deletion of the short arm of chromosome 6 is a recurrent aberration in thymoma.
URI: 
ISSN: 0165-4608
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
Medical Clerkships Centers
Laboratory for Genetics of Malignant Disorders
× corresponding author
# (joint) last author

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