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Title: Successful treatment with rituximab of lymphoproliferative disorder in a child after cardiac transplantation
Authors: Herman, Jean ×
Vandenberghe, Peter
van den Heuvel, Ingeborg
Van Cleemput, Johan
Winnepenninckx, Veronique
Lombaerts, Rita #
Issue Date: Dec-2002
Publisher: Mosby-Year Book
Series Title: The Journal of Heart and Lung Transplantation vol:21 issue:12 pages:1304-9
Abstract: Post-transplantation lymphoproliferative disorders (PTLDs) are life-threatening complications. We report the case of a 7-year-old girl in whom a lymphoproliferative disorder developed more than 2 years after cardiac transplantation. The patient was taking ganciclovir for Epstein-Barr virus hepatitis at the time the PTLD occurred. Rituximab, an anti-CD20 monoclonal antibody, given in the presence of reduced immunosuppression therapy, resulted in a complete response of the PTLD. The Epstein-Barr viral load in the peripheral blood, which was extremely high at diagnosis, dropped promptly and remained below the detection threshold 11 months after completion of therapy. We observed complete depletion of B lymphocytes until 7 months after rituximab therapy, which was associated with an important decrease in immunoglobulin levels.
URI: 
ISSN: 1053-2498
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
Cardiology
Laboratory of Pediatric Immunology
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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