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Title: Cytogenetic and clinical investigations in 76 cases with therapy-related leukemia and myelodysplastic syndrome
Authors: Iurlo, A ×
Mecucci, Christina
Van Orshoven, Angeline
Michaux, J L
Boogaerts, Marc
Noens, L
Bosly, A
Louwagie, Andries
Van den Berghe, Herman #
Issue Date: Feb-1990
Series Title: Cancer genetics and cytogenetics. vol:43 issue:2 pages:227-41
Abstract: Clinical, cytomorphologic, and cytogenetic investigations were carried out in a series of 76 secondary MDS and ANLL. Chromosome abnormalities were more frequent in patients with a history of multiple myeloma or macroglobulinemia (92%) and myeloproliferative disorders (82%) than in patients with previous breast cancer (40%). The secondary hematologic malignancies were mostly a trilineage bone marrow disorder. The most commonly found cytogenetic anomaly was monosomy 7, followed by total or partial loss of chromosome 5. In addition six other chromosomes, i.e., chromosome 3, 8, 9, 12, 17, and 21 seemed to be consistently involved in the pathogenetic mechanisms of secondary leukemia and MDS.
ISSN: 0165-4608
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hematology Section (-)
Clinical Genetics Section (-)
Clinical Genetics
× corresponding author
# (joint) last author

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