Title: Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005
Authors: Tyndall, Alan ×
Walker, Ulrich A
Cope, Andrew
Dazzi, Francesco
De Bari, Cosimo
Fibbe, Willem
Guiducci, Serena
Jones, Simon
Jorgensen, Christian
Le Blanc, Katarina
Luyten, Frank
McGonagle, Dennis
Martin, Ivan
Bocelli-Tyndall, Chiara
Pennesi, Giuseppina
Pistoia, Vito
Pitzalis, Constantino
Uccelli, Antonio
Wulffraat, Nico
Feldmann, Marc #
Issue Date: 2007
Publisher: BioMed Central Ltd.
Series Title: Arthritis Research & Therapy vol:9 issue:1 pages:301
Abstract: Multipotent mesenchymal stromal cells isolated from bone marrow and other sites are currently being studied to determine their potential role in the pathogenesis and/or management of autoimmune diseases. In vitro studies have shown that they exhibit a dose-dependent antiproliferative effect on T and B lymphocytes, dendritic cells, natural killer cells and various B cell tumour lines--an effect that is both cell contact and soluble factor dependent. Animal models of autoimmune disease treated with multipotent mesenchymal stromal cells have mostly exhibited a positive clinical response, as have a limited number of patients suffering from acute graft versus host disease. This review summarizes the findings of a 1-day meeting devoted to the subject with the aim of coordinating efforts.
ISSN: 1478-6354
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Rheumatology Section (-)
× corresponding author
# (joint) last author

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