Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005
Tyndall, Alan × Walker, Ulrich A Cope, Andrew Dazzi, Francesco De Bari, Cosimo Fibbe, Willem Guiducci, Serena Jones, Simon Jorgensen, Christian Le Blanc, Katarina Luyten, Frank McGonagle, Dennis Martin, Ivan Bocelli-Tyndall, Chiara Pennesi, Giuseppina Pistoia, Vito Pitzalis, Constantino Uccelli, Antonio Wulffraat, Nico Feldmann, Marc #
BioMed Central Ltd.
Arthritis Research & Therapy vol:9 issue:1 pages:301
Multipotent mesenchymal stromal cells isolated from bone marrow and other sites are currently being studied to determine their potential role in the pathogenesis and/or management of autoimmune diseases. In vitro studies have shown that they exhibit a dose-dependent antiproliferative effect on T and B lymphocytes, dendritic cells, natural killer cells and various B cell tumour lines--an effect that is both cell contact and soluble factor dependent. Animal models of autoimmune disease treated with multipotent mesenchymal stromal cells have mostly exhibited a positive clinical response, as have a limited number of patients suffering from acute graft versus host disease. This review summarizes the findings of a 1-day meeting devoted to the subject with the aim of coordinating efforts.