Title: Efficacy and safety of rituximab in B-cell post-transplantation lymphoproliferative disorders: results of a prospective multicenter phase 2 study
Authors: Choquet, Sylvain ×
Leblond, Veronique
Herbrecht, Raoul
Socié, Gérard
Stoppa, Anne-Marie
Vandenberghe, Peter
Fischer, Alain
Morschhauser, Franck
Salles, Gilles
Feremans, Walter
Vilmer, Etienne
Peraldi, Marie-Noelle
Lang, Philippe
Lebranchu, Yvon
Oksenhendler, Eric
Garnier, Jeanne Luce
Lamy, Thierry
Jaccard, Arnaud
Ferrant, Augustin
Offner, Fritz
Hermine, Olivier
Moreau, Anne
Fafi-Kremer, Samira
Morand, Patrice
Chatenoud, Lucienne
Berriot-Varoqueaux, Nathalie
Bergougnoux, Loïc
Milpied, Noel #
Issue Date: Apr-2006
Series Title: Blood vol:107 issue:8 pages:3053-7
Abstract: B-cell posttransplantation lymphoproliferative disorder (B-PTLD) is a rare but severe complication of transplantation, with no consensus on best treatment practice. This prospective trial, the first to test a treatment for PTLD, was designed to evaluate the efficacy and safety of rituximab in patients with B-PTLD after solid organ transplantation (SOT). Forty-six patients were included and 43 patients were analyzed. Patients were eligible if they had untreated B-PTLD that was not responding to tapering of immunosuppression. Treatment consisted of 4 weekly injections of rituximab at 375 mg/m2. At day (d) 80, 37 (86%) patients were alive, and the response rate was 44.2%, including 12 complete response/unconfirmed complete response (CR/CRu). The only factor predictive of a response at d80 was a normal lactate dehydrogenase level (P = .007, odds ratio [OR] = 6.9). At d360, responses were maintained in 68% of patients, and 56% of patients were alive. The overall survival rate at 1 year was 67%. We conclude that rituximab is effective and safe in PTLD, with stable responses at 1 year. The response rate and overall survival might be improved by combining rituximab with other treatments.
ISSN: 0006-4971
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science