Increased extracellular calcium concentrations in the isolated rat-heart - effects on mitochondrial contact site formation
Bakker, A De Bie, M Bernaert, I Ravingerova, T Ziegelhoffer, A Van Belle, Hubert Jacob, W #
Swets zeitlinger publishers
European journal of morphology vol:31 issue:1-2 pages:46-50
In our previous study, mitochondrial creatine kinase (Mi-CK) activity is localised cytochemically in heart tissue. The activity was found to be exclusively localised in mitochondrial contact sites and the surface density of Mi-CK was increased upon myocardial stimulation (Biermans et al., 1989). As calcium is involved as an intracellular messenger of stimulation, we compared hearts noradrenaline-stimulated in vivo with isolated hearts perfused with buffers containing different calciumconcentrations on the surface density Mi-CK.