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Title: Modulation of the effect of colchicine and cytochalasin B on fibroblast aggregates by the substratum
Authors: Van der Schueren, Bernadette
Cassiman, Jean-Jacques
Van den Berghe, Herman #
Issue Date: Sep-1978
Series Title: Journal of Cell Science vol:31 pages:355-67
Abstract: In previous investigations, we have shown that aggregates of normal human fibroblasts displayed a remarkable number of morphogenetic properties in suspension and on a substratum. The present investigation has attempted to illustrate more clearly the role of colchicine- and cytochalasin-sensitive structures in the observed ultrastructural properties of the fibroblasts in this system. Cytochalasin B and colchicine alter the surface ultrastructure of the cells as well as the behaviour of the cells during aggregate outgrowth. In addition, the effects of both drugs on the cells in the aggregates are modulated by the attachment of the aggregates to a substratum.
ISSN: 0021-9533
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Human Mutations and Polymorphisms Section (-)
Clinical Genetics Section (-)
Forensic Biomedical Sciences
# (joint) last author

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