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Title: Philadelphia chromosome-positive chronic myelogenous leukemia in treated Hodgkin's disease
Authors: Verhoef, Gregor ×
Demuynck, Hilde
Stul, M
Cassiman, Jean-Jacques
Mecucci, Christina
Van den Berghe, Herman
Boogaerts, Marc #
Issue Date: Nov-1990
Series Title: Cancer genetics and cytogenetics. vol:49 issue:2 pages:171-6
Abstract: A patient who developed Philadelphia (Ph) chromosome-positive chronic myelogenous leukemia (CML) 8 years after successful treatment for Hodgkin's disease (HD) is reported. The Ph chromosome with a typical 9(22) translocation was identified by banding techniques in 80% of bone marrow (BM) cells. Southern blot analysis showed breakpoint cluster region (BCR) rearrangement as observed in classical CML. Until now, only three cases of Ph + CML have been reported after treatment for HD. At present, it is not clear whether development of CML after HD represents a therapy-induced complication, an increased susceptibility to secondary malignancies owing to the malignant process itself, a consequence of the immunological deficiencies in HD, or possibly a genetic susceptibility to malignancy.
ISSN: 0165-4608
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Human Mutations and Polymorphisms Section (-)
Hematology Section (-)
Clinical Genetics Section (-)
Forensic Biomedical Sciences
Clinical Genetics
× corresponding author
# (joint) last author

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