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Title: Chromosomal anomalies in individuals with autism: a strategy towards the identification of genes involved in autism
Authors: Castermans, Dries ×
Wilquet, Valérie
Steyaert, Jean
Van de Ven, Willem
Fryns, Jean-Pierre
Devriendt, Koenraad #
Issue Date: Jun-2004
Publisher: SAGE Publications in association with the National Autistic Society
Series Title: Autism vol:8 issue:2 pages:141-161
Abstract: We review the different strategies currently used to try to identify susceptibility genes for idiopathic autism. Although identification of genes is usually straightforward in Mendelian disorders, it has proved to be much more difficult to establish in polygenic disorders like autism. Neither genome screens of affected siblings nor the large number of association studies using candidate genes have resulted in finding autism susceptibility genes. We focus on the alternative approach of 'positional cloning' through chromosomal aberrations in individuals with autism. In particular, balanced aberrations such as reciprocal translocations or inversions offer a unique opportunity, since only the genes in the breakpoint regions are candidate genes. This approach, in combination with others, is likely to produce results in the coming years.
ISSN: 1362-3613
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
Research Group Psychiatry
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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