Title: PREPL: a putative novel oligopeptidase propelled into the limelight
Authors: Martens, Kevin
Derua, Rita
Meulemans, Sandra
Waelkens, Etienne
Jaeken, Jacques
Matthijs, Gert
Creemers, John # ×
Issue Date: Jul-2006
Publisher: W. de Gruyter
Series Title: Biological Chemistry vol:387 issue:7 pages:879-883
Abstract: The prolyl endopeptidase-like protein PREPL has recently attracted attention because its gene is located within two contiguous gene-deletion syndromes, the 2p21 deletion syndrome and the hypotonia-cystinuria syndrome. Deletion of the gene results in hypotonia at birth, failure to thrive and growth hormone deficiency. PREPL is highly reactive against an activity-based probe, which indicates the presence of an intact catalytic machinery. However, no substrate has been found yet. The unique carboxy-terminus of the catalytic domain might contain the key to the as yet elusive specificity.
ISSN: 1431-6730
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
Associated Laboratories - miscellaneous (-)
Molecular Genetics Section (-)
Section Child - Miscellaneous (-)
Laboratory of Protein Phosphorylation and Proteomics
Laboratory of Phosphoproteomics (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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