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Title: Early motor development in young children with 22q.11 deletion syndrome and a conotruncal heart defect
Authors: Swillen, Ann ×
Feys, Hilde
Adriaens, Tamara
Nelissen, Loes
Mertens, Luc
Gewillig, Marc
Devriendt, Koenraad
Fryns, Jean-Pierre #
Issue Date: Dec-2005
Publisher: Heinemann William Medical Books
Series Title: Developmental Medicine and Child Neurology vol:47 issue:12 pages:797-802
Abstract: Velocardiofacial syndrome is identified by a submicroscopic deletion of chromosome 22q.11 (del22q.11). This study presents data on the early motor development and behaviour of 11 children (8 males, 3 females) with del22q.11 (mean age 41mo, SD 9.7mo) with a congenital heart defect. To control for the impact of the congenital heart defect, a control group of 19 children (15 males, 4 females; mean age 46mo, SD 9mo) with the same types of congenital heart defects but without del22q.11 was selected. Motor development in both groups was measured with the Peabody Developmental Motor Scales-2. Behaviour was assessed with the Child Behaviour Checklist. Children with del22q.11 scored significantly lower (p<0.05) on motor performance than the children of the control group. Most deficient motor skills were found for the subtests Locomotion and Stationary. On the behaviour questionnaire, a statistically significant (p<0.05) difference between the two groups was found only for the subscale Withdrawn. These data reveal a significant motor delay in many young children with del22q.11, which is not caused by the presence of a congenital heart defect or by behavioural features.
ISSN: 0012-1622
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
Section Child - Miscellaneous (-)
Research Group for Adapted Physical Activity and Psychomotor Rehabilitation
Research Group for Neuromotor Rehabilitation
Pediatric Cardiology Section (-)
Cardiovascular Developmental Biology
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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