Title: The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis
Authors: Van Damme, Philip ×
Leyssen, Maarten
Callewaert, Geert
Robberecht, Wim
Van Den Bosch, Ludo #
Issue Date: May-2003
Series Title: Neuroscience Letters vol:343 issue:2 pages:81-4
Abstract: alpha-Amino-3-hydroxy-5-methylisoxazole propionic acid (AMPA) receptor-mediated excitotoxicity has been implicated in the selective motor neuron loss in amyotrophic lateral sclerosis (ALS). The extent to which excitotoxicity contributes to motor neuron death remains incompletely understood. We therefore tested the potent and selective AMPA/kainate receptor antagonist 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide (NBQX) on motor neurons in culture and in the G93A mouse model for familial ALS. Kainate-induced currents and changes in intracellular Ca(2+) concentration were measured with the perforated patch clamp technique combined with Ca(2+) imaging, motor neuron death was quantified by counting experiments and G93A mice were treated with saline or 8 mg/kg NBQX. NBQX blocked kainate-induced currents and concomitant changes in intracellular Ca(2+), prevented the kainate-induced motor neuron death, and prolonged survival of G93A mice.
ISSN: 0304-3940
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Experimental Neurology
Physiology Section (-)
Laboratory for Neurobiology (Vesalius Research Center)
× corresponding author
# (joint) last author

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