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Title: P190 BCR/ABL transcript in a case of Philadelphia-positive multiple myeloma
Authors: Martiat, P ×
Mecucci, Christina
Nizet, Y
Stul, Michel
Philippe, M
Cassiman, Jean-Jacques
Michaux, J L
Van den Berghe, Herman
SOKAL, GERARD #
Issue Date: Dec-1990
Series Title: Leukemia vol:4 issue:11 pages:751-4
Abstract: Philadelphia positive multiple myeloma is a very rare event and, so far, no molecular data about the involvement of the BCR and C-ABL genes are available. We report here the case of a 64-year-old woman presenting with a typical multiple myeloma and a complex Philadelphia (Ph) chromosome that we investigated at a molecular level using conventional DNA techniques and the polymerase chain reaction (PCR). No rearrangement was observed within the major breakpoint cluster region (M-BCR) although she was found to have a P190 BCR/ABL hybrid transcript using PCR. As far as we know, this is the first description of a P190-type mRNA in a patient with a chronic lymphoid disorder. Since P190 is almost always associated in man with acute forms of hematological malignancies, this suggests that other factors may play a role in determining the phenotype of the disease.
ISSN: 0887-6924
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics
Forensic Biomedical Sciences
Human Mutations and Polymorphisms Section (-)
Clinical Genetics Section (-)
× corresponding author
# (joint) last author

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