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Title: Plasma exchange-associated immunoglobulin M-negative hantavirus disease after a camping holiday in Southern France
Authors: Keyaerts, Els ×
Ghijsels, Erik
Lemey, Philippe
Maes, Piet
Zachee, Pierre
Daelemans, Ronald
Vervoort, Tony
Mertens, Gerhard
Van Ranst, Marc
Clement, Jan #
Issue Date: May-2004
Publisher: Univ chicago press
Series Title: Clinical Infectious Diseases vol:38 issue:10 pages:1350-1356
Abstract: A 37-year-old Belgian patient presented with acute nephropathia epidemica (NE) shortly after a camping holiday in southern France. Unusual symptoms were initial noncardiogenic lung involvement, followed by severe acute renal failure, acute acalculous cholecystitis, presence of immunoblasts in the bone marrow, and hemolytic anemia, presenting as hemolytic uremic syndrome. Positive immunoglobulin (Ig) A and rising IgG titers against Puumala hantavirus (PUUV) were detected, but IgM remained negative on days 8 and 20. The results of reverse-transcriptase-polymerase chain reaction performed on day 8 were positive for PUUV. This is the first report of an iatrogenically IgM-negative hantavirus case due to the selective removal of heavyweight molecules during plasma exchange via the centrifugation technique. This is also the first report of proven NE from the Mediterranean part of France.
URI: 
ISSN: 1058-4838
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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