Title: Presenilins in memory, Alzheimer's disease, and therapy
Authors: Marjaux, Els ×
Hartmann, Dieter
De Strooper, Bart #
Issue Date: Apr-2004
Series Title: Neuron. vol:42 issue:2 pages:189-92
Abstract: Presenilins are considered to be the catalytic subunits of the gamma-secretase complex and are therefore drug targets for Alzheimer's disease. They are also essential for the fine tuning of the immunological system and for memory and synaptic plasticity. Genetic ablation in the forebrain results in a progressive neurodegenerative process that is independent from Abeta generation. The question arises as to what extent these observations should influence our thinking on the pathogenesis of Alzheimer's disease and on strategies to further develop gamma-secretase inhibitors.
ISSN: 0896-6273
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Genetics Section (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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