Title: Possible association of CD3 and CD4 polymorphisms with insulin-dependent diabetes mellitus (IDDM)
Authors: Ghabanbasani, M Z ×
Buyse, Inge
Legius, Eric
Decorte, Ronny
Marynen, Peter
Bouillon, Roger
Cassiman, Jean-Jacques #
Issue Date: Sep-1994
Series Title: Clinical and Experimental Immunology vol:97 issue:3 pages:517-21
Abstract: Population and family studies show that predisposition to type I diabetes (IDDM) is multifactorial, and that polymorphisms in the MHC region contribute substantially to the susceptibility to IDDM. In the present study the association of polymorphisms in the CD4 and the delta subunit of CD3 with IDDM were examined in a Belgian population. We observed that the frequency of the CD A4/A4 genotype and of the CD3 91 allele were significantly increased P = 0.0077) and decreased (P = 3.8 x 10(-5), respectively, in IDDM compared with controls. These results therefore suggest that CD4, CD3 or neighbouring genes might contribute to IDDM susceptibility. These results are, however, preliminary and cannot be considered as established until re-tested in a new population.
ISSN: 0009-9104
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Human Mutations and Polymorphisms Section (-)
Clinical Genetics Section (-)
Molecular Genetics Section (-)
Clinical and Experimental Endocrinology
Forensic Biomedical Sciences
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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