Title: Smads and chromatin modulation
Authors: Van Grunsven, Leonardus ×
Verstappen, Griet
Huylebroeck, Danny
Verschueren, Kristin #
Issue Date: Jul-2005
Series Title: Cytokine & growth factor reviews. vol:16 issue:4-5 pages:495-512
Abstract: Smad proteins are critical intracellular effector proteins and regulators of transforming growth factor type beta (TGFbeta) modulated gene transcription. They directly convey signals that initiate at ligand-bound receptor complexes and end in the nucleus with changes in programs of gene expression. Activated Smad proteins seem to recruit chromatin modifying proteins to target genes besides cooperating with DNA-bound transcription factors. We survey here the current and still emerging knowledge on Smad-binding factors, and their different mechanisms of chromatin modification in particular, in Smad-dependent TGFbeta signaling.
ISSN: 1359-6101
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Biology (Celgen) (-)
× corresponding author
# (joint) last author

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