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Title: "Spontaneous" FRA16B is a hot spot for sister chromatid exchanges
Authors: Lukusa, T ×
Meulepas, Ernest
Fryns, Jean-Pierre
Van den Berghe, Herman
Cassiman, Jean-Jacques #
Issue Date: Oct-1991
Series Title: Human Genetics vol:87 issue:5 pages:583-6
Abstract: Six heterozygous carriers of a fragile site at 16q22 were available for the current study. We demonstrated that the observed fragile site was a "BrdUrd-sensitive" fra(16)(q22) or FRA16B, capable of spontaneous expression in some individuals (= "spontaneous" FRA16B). Significant differences either in spontaneous or in ethylmethane sulfonate (EMS)-induced sister chromatid exchange (SCE) frequencies were found between the fragile 16q22 site, whether expressed or not, and its homologous normal site. These data complement our previous findings on FRAXA and provide additional arguments indicating that fragility and SCE are variable cytogenetic expressions of the same DNA structural alteration.
ISSN: 0340-6717
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
Human Mutations and Polymorphisms Section (-)
Forensic Biomedical Sciences
Laboratory for Genetics of Human Development
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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