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Title: dup(12)(q13----qter) in two t(14;18)-negative follicular B-non-Hodgkin's lymphomas
Authors: Wlodarska, Iwona ×
Mecucci, Christina
Vandenberghe, Elisabeth
De Wolf-Peeters, Christiane
Thomas, José
Hilliker, Carl
Schoenmakers, Erik
Stul, Michel
Marynen, Peter
Cassiman, Jean-Jacques
Van den Berghe, Herman
et al. #
Issue Date: Aug-1992
Series Title: Genes, chromosomes & cancer vol:4 issue:4 pages:302-8
Abstract: Two t(14;18)-negative follicular B-non-Hodgkin's lymphomas with the same chromosomal abnormality, dup(12)(q13----qter), are presented. The absence of a BCL2 gene rearrangement was confirmed by molecular studies in both cases. Instead, duplication of a 12q segment was found. Further evidence for the presence of the dup(12)(q13----qter) was found using fluorescence in situ hybridization. dup(12q) may be equivalent to the trisomy 12 originally described in B-chronic lymphocytic leukemia. This chromosome anomaly has also been reported in B-non-Hodgkin's lymphomas, usually in association with other chromosome anomalies and a more aggressive tumor phenotype. Occurrence of dup(12q) in two histologically similar cases of follicular small cleaved-cell lymphoma without a typical t(14;18), suggests that this karyotypic change may play a critical role in some cases of follicle center-cell lymphomas.
ISSN: 1045-2257
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Genetics of Malignant Disorders
Clinical Genetics
Translational Cell & Tissue Research
Department of Oncology - miscellaneous
Clinical Genetics Section (-)
Human Mutations and Polymorphisms Section (-)
Molecular Genetics Section (-)
Department of Human Genetics - miscellaneous
Forensic Biomedical Sciences
× corresponding author
# (joint) last author

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