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Title: Synthesis of 2-carbamoylmethyl-6-beta-D-ribofuranosylpyridine with the aid of a Pd(O)-catalyzed reaction
Authors: De Vos, E ×
Esmans, E L
Alderweireldt, F C
Balzarini, Jan
De Clercq, Erik #
Issue Date: Oct-1993
Publisher: Hetero corporation
Series Title: Journal of heterocyclic chemistry vol:30 issue:5 pages:1245-52
Abstract: D-Allo/D-altro-2-(2,4:3,5-di-O-benzylidenepentitol-1-yl)-6-ethoxycarbonylmethylpyridine was synthesized from 2-bromo-6-(2,4:3,5-di-O-benzylidenepentitol-1-yl)pyridine or 2-(2,4:3,5-di-O-benzylidenepentitol-1-yl)-6-iodopyridine by means of a tetrakis(triphenylphosphine)palladium(0)-catalyzed reaction with Reformatsky's reagent. Subsequent ammonolysis and mesylation of the D-altro-ethoxycarbonylmethyl compound gave D-altro-2-carbamoylmethyl-6-(1-O-mesyl-2,4:3,5-di-O-benzylidenepentitol-1-yl)pyridine which was cyclized to 2-carbamoylmethyl-6-beta-D-ribofuranoslpyridine.
ISSN: 0022-152X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Faculty of Pharmaceutical Sciences - miscellaneous
Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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